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‹Nr.›
Domain organization of N-WASp,
autoinhibition by GBD-VCA interaction, multiple effectors (Cdc42, PIP2,
Grb2, IcsA) for driving activation of Arp2/3 complex.
Conclusion: Functions and players required
for reconstitution of actin-based motility of Listeria or Shigella
or any particle. (Slide 17, 18-animation sketch).
Accordingly, branched filaments initiated
from ActA-coated beads are attached to the bead and branching points are at
equal distance from the ends of the two branches, again suggesting that
filaments branch from their barbed ends (Slide 14).
Topology of Arp2/3 complex, localization,
activation of polymerization by ActA. (Slide 10)
Physiological activators of Arp2/3 complex : the WASp family. (Slide
11).