Actin-based Motility

VASP increases the rate of detachment of the branched junction from ActA, allowing growth after branching

± VASP

k = 1.510-3s-1

ActA-coated beads

Y

V

Y

ActA in solution

V

Y

V

Y

V

Bead

Y

V

Filament

Arp2/3

ActA

VASP

k = 3.10-2s-1

+ VASP

Y

V

k = 2.5 10-4s-1

- VASP

Y

V

V

Y

Y

V

Y

V

- VASP

k = 1.510-3s-1

Y

ActA in solution

Y

Y

Y

Y

V

Y

+Y